To start click on the Data Upload tab of the top navigation bar.


MIENTURNET is an easy-to-use web tool devised for:

  1. receiving in input a list of genes and inferring possible evidences (computational or experimental) of miRNA regulation based on a statistical analysis for over-representation of miRNA-target interactions;
  2. receiving in input a list of mature miRNAs and inferring possible evidences (computational or experimental) of their regulation on target genes based on a statistical analysis for over-representation of miRNA-target interactions.

MIENTURNET makes use of computationally predicted or experimentally validated miRNA-target interactions, for several organisms, downloaded from TargetScan and miRTarBase, respectively. MIENTURNET allows to visualize the results as miRNA-target interaction network.

Requirements and availability

MIENTURNET web tool is free and open to all users. It was tested with Firefox Version >62, Google Chrome Version >69, Safari Version 12.0.2, Internet Explorer Version 11.

How to cite MIENTURNET

If you use MIENTURNET, please cite:

  • Licursi V et al. MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis. BMC Bioinformatics 20, 545 (2019) doi:10.1186/s12859-019-3105-x

[[HTML](https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-019-3105-x)] [[PDF](https://bmcbioinformatics.biomedcentral.com/track/pdf/10.1186/s12859-019-3105-x)]

MIENTURNET was created using the shiny package from RStudio, it has been developed by Valerio Licursi1,2, Federica Conte1, Giulia Fiscon1 and Paola Paci1.

1Institute for Systems Analysis and Computer Science “Antonio Ruberti”, National Research Council, Rome, Italy
2Department of Biology and Biotechnology “Charles Darwin”, “Sapienza” University of Rome, Italy

miRNA-target Enrichment analysis result


Hint: to order the table click on column names

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miRNA-target Enrichment analysis result


Hint: to order the table click on column names

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Network microRNA/Genes - TargetScan

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Network degree plots

Only the first 30 nodes will be visualized Save Degree Plots

Network microRNA/Genes - miRTarBase

Functional Enrichments for microRNA target genes

microRNA selected

microRNA selected

News and Release Notes


2023-08-09

NEWS: MIENTURNET is now upgraded to R version 4.3.1 and all the packages are now at the last version available. For Bioconductor packages the release is the 3.17.

Bug fixes:

  • Fixed issue that prevented enrichment analysis in KEGG and REACTOME.

2020-06-04

Bug fixes:

  • Fixed issue that prevented uploading a list of Rattus norvegicus miRNAs

2019-11-25

Bug fixes:

  • Fixed issue that prevented downloading mirTarBase network

2019-11-04

MIENTURNET paper is out in BMC Bioinformatics! Check it at https://doi.org/10.1186/S12859-019-3105-X or https://rdcu.be/bWrFM (readcube version)

2019-10-25

Bug fixes:

  • Fixed issue when there is no microRNAs in result table for Targetscan and miRTarBase
  • Faster loading of the application

2019-09-21

First release of MIENTURNET